Tag Archives: antiretroviral

Multiple sclerosis patient walks after taking HIV drugs

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A woman with multiple sclerosis (MS) says her symptoms improved so dramatically she was able to walk again after being prescribed HIV drugs.  Shana Pezaro, 36, from Hove, East Sussex, was given antiretroviral drugs after fearing she may have contracted HIV.  Within days, Miss Pezaro noticed an easing of her MS symptoms.

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When a doctor saw her walking up stairs after years of using a wheelchair he set up a clinical trial.

Multiple sclerosis is an incurable condition that can lead to sight loss, pain, fatigue and disability. It affects around 100,000 people in the UK.  In MS the coating around the nerve fibres is damaged causing a range of symptoms.  Once diagnosed there is no cure, but treatments can help manage the condition.

Physical symptoms of MS might commonly include vision problems, balance problems and dizziness, fatigue, bladder problems and stiffness and/or spasms.  MS can affect memory and thinking and also can have an impact on emotions.

Miss Pezaro was a dancer and piano teacher before being diagnosed with MS at the age of 28. The condition affected her hands and feet and she used a wheelchair.

About a year ago, Miss Pezaro thought she may have been exposed to HIV and her doctor prescribed emergency antiretroviral drugs.

“Three days after I took the drugs I walked up a flight of stairs,” she said.

“That was an unbelievable, massive change.”

Prof Julian Gold from the Prince of Wales Hospital in Sydney, saw a video of Miss Pezaro climbing the stairs and a clinical trial was set up to look at the impact of single or combination antiretroviral drugs on MS patients.

An earlier study led by Dr Gold conducted with Queen Mary University, London and the University of Oxford showed an association between HIV and MS.

They reported antiretroviral treatment may suppress other viruses such as those which may cause MS.

Dr Gold said: “The next stage of the investigation is to use a very similar combination [of HIV drugs] that Shana took. I think that might be quite optimistic.”

A spokeswoman for the MS Society said: “Our growing understanding tells us that viruses have a role to play in multiple sclerosis and it will be interesting to see the trial results – positive findings mean another step on the road to beating MS.”

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Drugging Our Way Out of the HIV Epidemic

When antiretroviral drug cocktails hit the scene in 1996, they were so effective they became known as ‘the Lazarus drug.’ Many AIDS patients recovered seemingly overnight. Over the past 15 years, these drugs have saved the lives of millions of people infected with HIV. Several new studies suggest antiretrovirals could save millions more if we start using them for prevention as well as treatment.

Last July, researchers reported that a vaginal gel laced with an antiretroviral called tenofovir reduced HIV acquisition among South African women by 39% overall and by 54% in women who used the gel faithfully. Then, in November, a separate team of researchers reported that an oral antiretroviral pill taken daily reduced the risk of HIV infection among men who have sex with men by 44%. This year, on May 11, researchers announced the results of another study. They found that HIV-infected individuals — both men and women — who took antiretroviral drugs were a whopping 96% less likely to pass the virus on to their partners than individuals who didn’t take the drugs. The results are preliminary, but Myron Cohen, the HIV researcher who led the study and spoke on Monday at the New York Academy of Sciences, said he is confident that the large effect will hold.

These fantastic results beg the question: Can we drug our way out of the HIV epidemic?

Researchers have long suspected that people who take antiretrovirals are less likely to pass HIV on to their sexual partners. The idea makes a lot of biological sense. Antiretroviral drugs stop HIV from replicating, which means fewer copies of the virus floating around in HIV patients’ blood and, presumably, their genital secretions. But the hypothesis had never been proven in a randomized clinical trial. So in 2005, Cohen began a study to test the hypothesis.

He and his colleagues recruited 1,763 discordant couples—meaning one person was infected with HIV and the other wasn’t—in Botswana, Brazil, India, Kenya, Malawi, South Africa, Thailand, the US, and Zimbabwe. They randomly assigned each couple to one of two groups. In the first group, HIV-infected individuals received antiretrovirals right away. In the second group, the researchers more or less followed the standard treatment guidelines, delaying treatment until the disease progressed.

On April 28, the independent committee charged with overseeing the trial met at the National Institutes of Health for their tenth meeting. At each meeting, the committee members would review the data and decide whether the trial should continue. After this most recent meeting, they told Cohen they had a recommendation, but they couldn’t yet tell him what it was. Cohen, who has never been allowed to see the results, assumed the worst—that the early treatment hadn’t worked. Then he received a phone call. The committee told him they had seen such a dramatic benefit that they wanted to release the results.

On May 11, Cohen held a press conference to announce the results. During the study, 28 individuals had become infected with their partner’s strain of virus. But only one of those infections occurred in the early treatment group. The other 27 infections occurred in couples not taking antiretrovirals.

Ever since the press conference, Cohen has been inundated with media requests. The success is well deserved. HIV prevention researchers have been working long and hard for decades with little to show for it (One notable exception: The 2007/2008 circumcision trials, which found that male circumcision can cut a man’s risk of contracting HIV by 50%).

On Monday, Cohen compared the trial to “pushing a boulder up a hill.” But I think the most daunting challenge lies ahead. How do you take all these positive results – not just from Cohen’s study, but from the others as well – and develop an effective public health strategy?

Cohen found that early treatment can prevent new infections. So putting everyone who has HIV on treatment immediately should dramatically curb the spread of HIV. But antiretrovirals are expensive. Advocate for earlier treatment, and you dramatically increase the number of people who need pills. According to the World Health Organization, roughly 33 million people are infected with HIV. Of those, five million are receiving treatment. Another 10 million aren’t taking antiretrovirals but should be. So to prevent new infections, we need provide treatment to between 10 million and 28 million people. Who will pay for their medicine? Many of the people infected with HIV barely earn enough to feed themselves, let alone purchase expensive drugs.

And what about all the individuals who are infected with HIV but don’t know it? People seem to be most infectious right after they become infected themselves. Studies suggest that anywhere between 8% and 40% of new infections are caused by people who are in this “acute” stage. But people with acute infections often test negative for the virus because they haven’t yet developed antibodies. So how do you find these people?

Here’s another issue. Millions of people infected with HIV depend on antiretrovirals for their survival. So if we want to use antiretrovirals for prevention, we need to find a way to do it without creating more drug resistance. How?

Although answering these questions may prove challenging, I’m [sic] not suggesting we should throw in the towel. Science is giving us the data, now it’s up to us to decide how to use it. Antiretrovirals aren’t the long-awaited magic bullet that will end the HIV epidemic — we can’t drug our way out of this — but they can save lives and prevent new infections. It’s a start.

Via: http://www.lastwordonnothing.com/2011/05/18/drugging-our-way-out-of-the-hi-epidemic/
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